Index
1001
a-D-mannosidase, 169
Mannosidosis, 169
MAP kinase, 738
MAP kinase pathway,
8 8 6
Maple syrup urine disease (branched-chain
ketoaciduria), 20, 352, 915
Marasmus, 333
Marfan’s syndrome, 180, 590
Markers
bone formation, 889
bone resorption, 889
Mast cells, 808
Maternal IgG, 187
Maternally inherited, 266
Maternally inherited disease, 269
Maturity-onset diabetes of the young
(MODY), 493
Maxam, alan, 536
Maxam-Gilbert method, 536
MB, 472
McArdle’s syndrome, 12
McCune-Albright syndrome, 604, 717, 772
McKees rocks, 667
Mdm-2, 611
Measurement of enzyme activity, 124
Measurement of pH, 11
Mechanism of action of heparin as a
therapeutic anticoagulant, 859
Mechanism of contraction, 466
cross-bridge cycling, 466
Mechanism of contraction:
excitation/contraction coupling, 464
Mechanism of oxygenation, 650
Mechanism-based enzyme inactivation, 95
Mecillinam, 327
Meconium ileus, 221
Medgestrol acetate, 800
Median eminence, 729
Medium-chain acyl-CoA dehydrogenase
(MCAD) deficiency, 369
Medium-chain fatty acids, 217
Medium-chain triacylglycerols, 217
Medroxyprogesterone acetate, 800
Medullary carcinoma,
8 8 8
Megaloblastic anemia, 915, 918
Megaloblastosis, 922
Meglitinides, 515
Melanin, 360, 508
biosynthesis of, 360
Melanocortin-4 receptor (MC4-R), 82,
516,517
Melanocyte stimulating hormone
(y-MSH), 82, 744
a-melanocyte, 517
y-melanocyte stimulating hormone, 744
Melanoma, colorectal, 611
Melanoma, neurofibromatosis type 1,
neuroblastoma, 612
MELAS (mitochondrial encephalopathy),
478
Melatonin, 508
sleep, 362
biosynthesis of, 362
Melphalan, 953
Melting curve, 527
Melting temperature, 528
Melting temperature of DNA, 528
Membrane attack complex, 808
Membrane filtration, 37
Membrane phospholipid surfaces, 851
Membrane proteins
peripheral (extrinsic), 156
peripheral (intrinsic), 156
Membrane(s)
asymmetry, 161
cholesterol content, 158
fluidity, 158
lipid bilayer, 161
plasma, 159
skeleton, 164
skeleton proteins, 163
Membranous, 951
MEN-1,612
MEN I syndrome,
8 8 6
MEN II syndrome,
8 8 6
MEN syndrome,
8 8 6
Menke’s syndrome, 897
Menkes’ (kinky-hair) syndrome,
590, 897
Menkes’ syndrome, 897
Menorrhagia, 679
Menstrual cycle, 790
Mental retardation, 298, 561
Mercaptoethanol, 36
6
-mercaptopurine, 627
Merodesmosine, 24
MERRF variants, 270
Mesangial cells, 514
Mesocorticolimbic neuronal terminals,
379
Messenger RNA (mRNA), 563, 564
Mestranol, 800
Met-enkephalin (MENK), 734, 735
Metabolic acidosis, 936
Metabolic activity, 486
Metabolic alkalosis, 937
Metabolic degradation of uric acid, 630
Metabolic diseases: glycogen storage
diseases, 478
Metabolic functions of ascorbate, 926
Metabolic homeostasis, 485
abnormalities, 511,515
during exercise, 517
Metabolic roles of organs, 487
Metabolic scope, 468
Metabolic, endocrine, 766
Metabolism
fructose and sorbitol, 296
galactose, 297
Metabolism of amino sugars, 298
Metabolism of ammonia, 340
Metabolism of cobalamins in mammalian
cells, 919
Metabolism of corticosteroids, 754
Metabolism of estrogen, 797
Metabolism of testosterone, 785
Metal cofactors, 108
Metal ions, 32
Metallothioneins, 894, 898
Metanephrine, 762
Metformin, 515
Methane, 202
Methanol, 96
intoxication, 96
Methemoglobin, 101, 672
Methemoglobin reductase,
6 6 8
Methemoglobinemia
hereditary, 672
Methionine, 21,214, 279, 331, 353,
508, 702
Methionyl-tRNA synthetase, 574
Methotrexate, 617
3-methoxy-4-hydroxyphenyl glycol, 762
3-methoxy-4-hydroxymandelic acid, 763
Methyl groups can be added to bases, 524
Methyl xanthines, 465
Méthylation, 524, 604
Méthylation of bases, 524
Méthylation of DNA, 556
enzymes responsible for, 524
Methylene blue, 673
3- methylcrotonyl glycinuria, 353
Methylenecyclopropylacetyl-CoA, 352
N
5
,N’ °-methy lenetetrahydrofolate,
344, 347
Methylfolate trap hypothesis, 922
Methylhistidine excretion, 458
Methylmalonic aciduria, 922
Methylmalonyl-CoA, 244
Methylmalonyl-CoA mutase, 922
Methylmalonyl-CoA-mutase precursor
protein, 267
Méthylprednisolone, 752
4- methylpyrazole (fomepizole), 97
Metronidazole, 145
Metyrapone, 707
Mevalonate
conversion to isoprenyl
pyrophosphate, 419
Mg2+ ion, 108
MHC I protein, 820
MHC II protein, 822
Micelles, 3, 201, 217
Michaelis constant,
K
m, 89, 91
